The PapillomaVirus Episteme (PaVE) has been established to provide information and bioinformatics resources to the scientific community for research on the Papillomaviridae family of viruses. The PaVE consists of a relational database and web applications that support the storage, annotation, analysis, and exchange of information. PAVE can be found at http://pave.niaid.nih.gov PaVe contains genomic and protein sequences for all papillomaviruses. It includes a multiple sequence alignment tool, a protein structure viewer, a viral typing tool and an Image viewer for visualizing clinical manifestations of viral infection. Linked review articles provided detailed information about all aspects of functional genomics of papillomaviruses. In FY2019, the PaVE database and website was updated and now contains 649 annotated papillomavirus genomes (including 244 Non-reference genomes), 7236 genes and regions, 5297 protein sequences, and 70 protein structures, which users can explore, analyze or download. This resource is invaluable for the papillomavirus research community. As of May 2019, it had been accessed >28,000 times,had users in 136 countries and has been cited >350 times on Google Scholar